Research Areas

Molecular Medical Imaging

Using synthetic apporaches to molecular imaging agents for clinical use (Key papers: Pharmaceuticals 2020, 13, 296; ACS Omega 2020, 5, 22071-22080; ChemComm 2019, 55, 10784-10787, Curr. Opin. Biotech. 2019, 58, 9-18).

Photopharmacology

Establishing light-control over the biological activity of drugs for their activation with high precision in space and time (Key papers: J. Am. Chem. Soc. 2019, 141, 14356-14363; Trends Biochem. Sci. 2018, 43, 567-575; J. Am. Chem. Soc 2017, 139, 1797917986; Angew. Chem. Int. Ed. Engl. 2016, 10978-10999; J. Am. Chem. Soc., 2014, 21782191; Nature Chem., 2013, 924928; Chem. Eur. J., 2015, 16517-16524; Chem. Sci., 2015, 3593-3598).

Molecular photoswitches

Synthesis, photochemistry and the development of new methods for the incorporation of molecular photoswitches into biomolecules (Key papers: Chem. Sci., 2020, 11, 11672-11691; Angew. Chem. Int. Ed. 2020, ASAP; Nat. Commun. 2019, 10, 2390; Angew. Chem. Int. Ed. 2018, 57, 8063-8068; Chem. Soc. Rev. 2018, 1910-1937, Angew. Chem. Int. Ed. 2016, 1351413518, Nature Communications 2016, 12054; J. Am. Chem. Soc., 2016, 63446347; Chem. Rev., 2013, 61146178; Angew. Chem. Int. Ed. 2013, 2068-2072).

Photocaging and photocleavable protecting groups (PPGs)

Using PPGs for regulating bilogical activity of drugs, also in wavelenghth-selective systems (Key papers: ChemComm 2020, 56, 5480-548, J. Org. Chem. 2018, 83, 1819-1827; Chem. Soc. Rev., 2015, 3358-3377; Angew. Chem. Int. Ed. Engl. 2014, 86828686; ACS Chem. Biol., 2014, 19691974).

Biocatalysed ammonia addition to olefinic bonds

Using ammonia lyases for asymetric conjugate addition of ammonia to cinnamic and mesaconic acids (Key papers: Nature Chem., 2012, 478484; Angew. Chem. Int. Ed., 2012, 482486; J. Org. Chem., 2009, 91529157).

Biocatalysed hydroxy-de-halogenation

Using haloalkane dehalogenases and halohydrin dehalogenases for epoxide formation/opening and the hydrolysis of haloalkanes in KR, DKR, desymmetrisation and enantioconvergent processes (Key papers: Angew. Chem. Int. Ed., 2011, 1071210715; Adv. Synth. Cat. 2010, 21112115; Chem. Commun., 2010, 898-900).