Research Areas

Molecular Medical Imaging

Using synthetic apporaches to molecular imaging agents for clinical use (Key papers: Pharmaceuticals 2023, 16, 1439; J. Am. Chem. Soc. 2021, 143, 10041-10047; Pharmaceuticals 2020, 13, 296; ACS Omega 2020, 5, 22071-22080; ChemComm 2019, 55, 10784-10787, Curr. Opin. Biotech. 2019, 58, 9-18).

Photopharmacology

Establishing light-control over the biological activity of drugs for their activation with high precision in space and time (Key papers: J. Am. Chem. Soc. 2024, ASAP; Angew. Chem. Int. Ed. 2023, 62, e202300681; Nat. Comm. 2021, 12, 3164; J. Am. Chem. Soc. 2021, 143, 1513-1520; J. Am. Chem. Soc. 2019, 141, 14356-14363; Trends Biochem. Sci. 2018, 43, 567-575; J. Am. Chem. Soc 2017, 139, 1797917986; Angew. Chem. Int. Ed. Engl. 2016, 10978-10999; J. Am. Chem. Soc., 2014, 21782191; Nature Chem., 2013, 924928; Chem. Eur. J., 2015, 16517-16524; Chem. Sci., 2015, 3593-3598).

Molecular photoswitches

Synthesis, photochemistry and the development of new methods for the incorporation of molecular photoswitches into biomolecules (Key papers: J. Am. Chem. Soc. 2023, 145, 36, 1989419902; ChemPhotoChem 2022, 6, e202200170; Angew. Chem. Int. Ed. 2021, 60, 25290-25295, Chem. Sci., 2021, 12, 4588-4598; Chem. Sci., 2020, 11, 11672-11691; Angew. Chem. Int. Ed. 2020, 59, 21663-21670; Nat. Commun. 2019, 10, 2390; Angew. Chem. Int. Ed. 2018, 57, 8063-8068; Chem. Soc. Rev. 2018, 1910-1937, Angew. Chem. Int. Ed. 2016, 1351413518, Nature Communications 2016, 12054; J. Am. Chem. Soc., 2016, 63446347; Chem. Rev., 2013, 61146178; Angew. Chem. Int. Ed. 2013, 2068-2072).

Photocaging and photocleavable protecting groups (PPGs)

Using PPGs for regulating bilogical activity of drugs, also in wavelenghth-selective systems (Key papers: Chem. Sci. 2024, ASAP; J. Am. Chem. Soc. 2022, 144, 12421-12430; Angew. Chem. Int. Ed. 2022, 61, e202201308; ChemComm 2020, 56, 5480-548; J. Org. Chem. 2018, 83, 1819-1827; Chem. Soc. Rev., 2015, 3358-3377; Angew. Chem. Int. Ed. Engl. 2014, 86828686; ACS Chem. Biol., 2014, 19691974).