Functional molecules: Medical Imaging

MI1: Vancomycin-IRDye700DX conjugate (Optical Imaging / Theranostics)

Key features: MI1 is an antimicrobial photodynamic therapy (aPDT) agent that binds selectively to Gram-positive bacteria and causes their eradication through red light-induced formation of reactive oxygen species.


Photochemistry: 680-700 nm


Creators: Friederike Reessing, Mafalda Bispo

Literature: paper 1

MI2: Amphotericin B-IRDye800CW conjugate (Optical Imaging)

Key features: MI2 is a fluorescent optical imaging agent for diagnostics of fungal infections. It is excited and fluoresces in NIR region of the spectrum, and is based on IRDye800CW that has been used in human studies before.


Photochemistry: 774 nm (ex) 789 nm (em)


Creators: Friederike Reessing, Mafalda Bispo

Literature: paper 1

MI3: Light-responsive MRI contrast agent (Magnetic Resonance Imaging)

Key features: MI3 is a smart MRI contrast agent that changes its relaxivity by up to 20% at clinical MRI scanner magnetic fields (1.5T and 3T) in response to irradiation with violet light of 400 nm.


Photochemistry: 360-400 nm


Creators: Friederike Reessing

Literature: paper 1

MI4: Light-responsive liposomes for MRI-followed drug delivery (Theranostics)

Key features: MI4 MI4 forms liposomes with DOPC, resulting in light-triggered nano-containers for cargo delivery. Uniquely, both the distribution and the photoactivated cargo release form those liposomes can be followed in real time with MRI.


Photochemistry: 360-400 nm


Creators: Friederike Reessing

Literature: paper 1

MI5: PET tracer for prostate cancer diagnostics (Positron Emission Tomography)

Key features: MI5 is a PET tracer for the imaging of prostate cancer and its metastasis that selectively binds to the Prostate-Specific Membrane Antigen. It is created in a modular way through click chemistry, which opens the possibilities of alternative functionalisation.


Creators: Verena Boehmer

Literature: paper 1